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furthermore, fluoxetine treatment resulted in a decrease in estradiol concentrations, whereas the levels of the steroids cortisol and progesterone remained unchanged (Domingues et al., 2023a)

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A study in children’s CSF found that 17 of the 30 metabolites they studied were associated with age, suggesting that an understanding of metabolomic changes with age is critical when assessing neurometabolic disease ( 47 )

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